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Search Results for " serine protease 1 "
Targets Recommended: Others Serine Protease

21

抑制剂 & 化合物

5

天然产物

1762

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T13408 ZK824190

Others; Serine Protease Others; Proteases/Proteasome
ZK824190 是具有口服活性尿激酶型纤溶酶原激活剂 (uPA) 选择性抑制剂,对 uPA,tPA 和 Plasmin 的IC50分别为 237,1600 和 1850 nM。ZK824190在多发性硬化症中有研究价值。
T13257 Upamostat

PAI-1; Serine/threonin kinase; Serine Protease Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
Upamostat 是一种丝氨酸蛋白酶抑制剂,也是一种具有口服活性的 WX-UK1 前药,是一种尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。
T4317 PF 429242

NPC1L1; Lipid Membrane transporter/Ion channel; Metabolism
PF 429242 是甾醇调节元件结合蛋白 (SREBP) 位点 1 蛋白酶的竞争性抑制剂 (IC50 = 0.175 μM)。它对位点 1 蛋白酶对一组丝氨酸蛋白酶具有选择性。 PF-429242 抑制 CHO 细胞中胆固醇的合成速率 (IC50 = 0.53 μM)。
T6190 Telaprevir

VX-950,LY-570310,Incivek,MP-424,特拉匹韦

HCV Protease; SARS-CoV Microbiology/Virology; Proteases/Proteasome
Telaprevir (Incivek) 是一种选择性可逆的HCV NS3-4A 蛋白酶抑制剂,作用于基因 1型 (H 株) NS3 蛋白酶结构域和 NS4A 辅因子肽,Ki 为 7 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T3226 Paritaprevir

ABT-450,Veruprevir,帕利瑞韦

HCV Protease Microbiology/Virology; Proteases/Proteasome
Paritaprevir (ABT-450) 是一种口服生物可利用的合成酰基磺酰胺抑制剂,可抑制丙型肝炎病毒 (HCV) 蛋白酶复合物,由非结构蛋白 3 和 4A (NS3/NS4A) 组成,对 HCV 基因型 1 具有潜在活性。 给药后,paritaprevir 可逆地结合 HCV NS3/NS4A 蛋白酶的活性中心和结合位点,并阻止 NS3/NS4A 蛋白酶介导的多蛋白成熟。这会破坏病毒蛋白的加工和病毒复制复合物的形成,从而抑制病毒在 HCV 基因型 1 感染的宿主细胞中的复制。 NS3 是一种丝氨酸蛋白酶,对于 HCV 多蛋白内多个位点的蛋白水解切割至关重要,并且在 HCV 核糖核酸 (RNA) 复制过程中起关键作用。 NS4A 是 NS3 的激活因子。 HCV 是属于黄病毒科的一种小的、有包膜的单链 RNA 病毒,感染与肝细胞癌 (HCC) 的发展有关。
T10082 DPP-IV-IN-1

Others Others
DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).
T76157 Chymotrypsinogen

Chymotrypsinogen 是Chymotrypsin 的无活性前体。Chymotrypsinogen 是一种由胰腺产生的丝氨酸蛋白酶 (serine protease)。
T74576 Manusiran

Manusiran 是一种有效的TMPRSS6(跨膜蛋白酶丝氨酸 6) 合成抑制剂。
TP1628 Activated Protein C (390-404), human

Activated Protein C (390-404), human, a peptide derived from the vitamin K-dependent serine protease, effectively suppresses the anticoagulant activity of APC[1].
T76202 Recombinant Proteinase K

Recombinant Proteinase K为一种serine protease,专门裂解脂肪族及芳香族氨基酸的羧基端肽键,适用于蛋白质消化与清除核酸制剂中的污染。
T14555 BI-1230

HCV Protease Microbiology/Virology; Proteases/Proteasome
BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between other serine/cysteine proteases. Additionally, BI-1230 exhibits favorable pharmacokinetic (PK) properties[1].
T76489 Fluorescent Substrate for Subtillsin

Fluorescent Substrate for Subtilisin 是一种用于检测 Subtilisin 酶活的荧光底物。Subtilisin 是一种来自细菌的丝氨酸蛋白酶。
T73701 Urokinase (peptidolytic)

Urokinase peptidolytic (Urokinase-type plasminogen activator) 是一种丝氨酸蛋白酶,是丝氨酸蛋白酶纤溶酶的一种非活性形式(酶原)。纤溶酶的激活可触发蛋白水解级联反应,进而参与血栓溶解或细胞外基质降解,涉及血管疾病和癌症相关研究。
T11269 FD-IN-1

Others Others
FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system.
T80094 Dansyl-Glu-Gly-Arg-Chloromethylketone

Dansyl-Glu-Gly-Arg-Chloromethylketone,一种蛋白酶抑制剂,特异性针对丝氨酸/苏氨酸蛋白酶。此化合物有效抑制活化猪因子IX。
TP1656 VIR-165

VIR-165 is a modified form of virus inhibitory peptide (VIRIP), which corresponds to residues 353 to 372 of C-proximal region of human alpha1-antitrypsin, the most abundant circulating serine protease inhibitor. VIRIP inhibits a wide variety of human immu
T78354 Subtilisin

EC 3.4.21.14

Subtilisin,一种细菌来源的丝氨酸蛋白酶,通常作为洗涤剂添加剂使用,特征包括热稳定性、对pH的耐受性和钙依赖性稳定性。
T80059 Complement factor I

Endogenous Metabolite Metabolism
Complement factor I,一丝氨酸蛋白酶,可与辅助因子H (FH)、补体受体1 (CR1/CD35)、C4结合蛋白 (C4BP) 或膜辅助因子蛋白 (MCP/CD46) 结合,调控液相及/或细胞表面补体系统的活性。
T75394 Picornain 3C

Picornain 3C为发现于小核糖核酸病毒中的蛋白酶,具有切割非末端序列肽键的能力。该酶是丝氨酸肽酶胰凝乳蛋白酶与半胱氨酸肽酶木瓜蛋白酶中间产物,展示内肽酶活性。特别地,Picornain 3C选择性切割脊髓灰质炎病毒多聚蛋白中的Gln-Gly键,以及在其他小核糖核酸病毒中,Gln被Glu替代,Gly被Ser或Thr替代的情况下亦能切割。
T38052 CRA-2059 TFA

CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2]. Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research[1]. [1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002;16...
T38051 CRA-2059 hydrochloride

CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2]. Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 hydrochloride has the potential for inflammatory bowel disease research[1]. [1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Ali...

化合物

ZK824190
Cat.No: T13408
Synonym:
Target: Others, Serine Protease
Upamostat
Cat.No: T13257
Synonym:
Target: PAI-1, Serine/threonin kinase, Serine Protease
PF 429242
Cat.No: T4317
Synonym:
Target: NPC1L1, Lipid
Telaprevir
Cat.No: T6190
Synonym: VX-950,LY-570310,Incivek,MP-424,特拉匹韦
Target: HCV Protease, SARS-CoV
Paritaprevir
Cat.No: T3226
Synonym: ABT-450,Veruprevir,帕利瑞韦
Target: HCV Protease
DPP-IV-IN-1
Cat.No: T10082
Synonym:
Target: Others
Chymotrypsinogen
Cat.No: T76157
Synonym:
Target:
Manusiran
Cat.No: T74576
Synonym:
Target:
Activated Protein C (390-404), human
Cat.No: TP1628
Synonym:
Target:
Recombinant Proteinase K
Cat.No: T76202
Synonym:
Target:
BI-1230
Cat.No: T14555
Synonym:
Target: HCV Protease
Fluorescent Substrate for Subtillsin
Cat.No: T76489
Synonym:
Target:
Urokinase (peptidolytic)
Cat.No: T73701
Synonym:
Target:
FD-IN-1
Cat.No: T11269
Synonym:
Target: Others
Dansyl-Glu-Gly-Arg-Chloromethylketone
Cat.No: T80094
Synonym:
Target:
VIR-165
Cat.No: TP1656
Synonym:
Target:
Subtilisin
Cat.No: T78354
Synonym: EC 3.4.21.14
Target:
Complement factor I
Cat.No: T80059
Synonym:
Target: Endogenous Metabolite
Picornain 3C
Cat.No: T75394
Synonym:
Target:
CRA-2059 TFA
Cat.No: T38052
Synonym:
Target:
CRA-2059 hydrochloride
Cat.No: T38051
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T75648 Rivulariapeptolides 1155

Rivulariapeptolides 1155 是一种有效的丝氨酸蛋白酶 (serine protease) 抑制剂,对糜蛋白酶、弹性蛋白酶、蛋白蛋白酶 K 的 IC50分别为 41.84、4.94、56.54 nM。
T75649 Rivulariapeptolides 1185

Rivulariapeptolides 1185 是一种高效的选择性丝氨酸蛋白酶抑制剂,其对胰凝蛋白酶、弹性蛋白酶和蛋白酶 K 的 IC50分别为 13.17 nM、23.59 nM 和 55.26 nM。
T75651 Rivulariapeptolides 988

Rivulariapeptolides 988作为一种高效选择性丝氨酸蛋白酶抑制剂,对胰凝蛋白酶、弹性蛋白酶和蛋白酶K的IC50分别为95.46 nM、15.29 nM和85.50 nM。
T75652 Molassamide B

Molassamide B,丝氨酸蛋白酶抑制剂,对胰凝乳蛋白酶、弹性蛋白酶及蛋白酶 K 具有显著抑制活性,其IC50值分别为24.65、11.69和5.42 nM。
T75650 Rivulariapeptolides 1121

Rivulariapeptolides 1121,作为一种高效的选择性丝氨酸蛋白酶抑制剂,对胰凝蛋白酶、弹性蛋白酶和蛋白酶K展示出了显著的抑制活性,其IC50值分别为35.52 nM、13.24 nM和48.05 nM。

天然产物

Rivulariapeptolides 1155
Cat.No: T75648
Synonym:
Target:
Rivulariapeptolides 1185
Cat.No: T75649
Synonym:
Target:
Rivulariapeptolides 988
Cat.No: T75651
Synonym:
Target:
Molassamide B
Cat.No: T75652
Synonym:
Target:
Rivulariapeptolides 1121
Cat.No: T75650
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-00905 Prostasin/PRSS8 Protein, Human, Recombinant (His)

CAP1,protease, serine, 8,PROSTASI...

Human HEK293 Cells
Prostasin/PRSS8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q16651-1.
TMPJ-00452 Serpin A1a Protein, Mouse, Recombinant (His)

Alpha-1-antitrypsin 1-1, Alpha-

Mouse HEK293 Cells
Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
TMPJ-01069 Serpin A1e Protein, Mouse, Recombinant (His)

Dom5,α-1-antitrypsin 1-5,Serpina1...

Mouse HEK293 Cells
Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein ...
TMPJ-00980 Complement Factor MASP3 Protein, Human, Recombinant (His)

PRSS5,CRARF,Serine Protease 5,MASP1

Human HEK293 Cells
MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway. The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of microorganisms. Activation of the complement pathway via MBL is initiated by specific MASPs. Three MASPs have been identified and all have domain structures similar to those of C1r and C1s with a heavy chain (chain A) and a light chain (chain B). Chain A is composed of CUB1, EGF, CUB2...
TMPY-02783 Prostasin/PRSS8 Protein, Mouse, Recombinant (aa 30-289, His)

C79772,CAP1,protease, serine, 8,f...

Mouse Baculovirus Insect Cells
Prostasin/PRSS8 Protein, Mouse, Recombinant (aa 30-289, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 29.3 kDa and the accession number is EDL17608.1.
TMPJ-01083 Serpin E2 Protein, Mouse, Recombinant (His)

Pi7,Protease nexin I,Spi4,Pn1,Serine

Mouse HEK293 Cells
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser...
TMPJ-00468 KLK10 Protein, Human, Recombinant (His)

Kallikrein-10,Protease Serine-Lik...

Human HEK293 Cells
KLK10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 34 KDa and the accession number is AAH02710.1.
TMPJ-00733 SPINK1 Protein, Human, Recombinant (His)

PSTI,Pancreatic Secretory Trypsin Inhibitor,TATI,Serine<...

Human HEK293 Cells
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE ...
TMPH-03242 Anionic trypsin-1 Protein, Rat, Recombinant (E. coli, His)

Pretrypsinogen I,Cationic trypsinogen,Try1,Beta-try...

Rat E. coli
N/A. Anionic trypsin-1 Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 27.2 kDa and the accession number is P00762.
TMPH-03243 Anionic trypsin-1 Protein, Rat, Recombinant (His)

Pretrypsinogen I,Anionic trypsin I,Try1,Trp1

Rat P. pastoris (Yeast)
N/A. Anionic trypsin-1 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 23.1 kDa and the accession number is P00762.
TMPH-00484 Cationic trypsin Protein, Canine, Recombinant (His & SUMO)

TRP1,Serine protease 1,P...

Canine E. coli
Cationic trypsin Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli.
TMPJ-01204 TPSAB1 Protein, Human, Recombinant (His)

TPS1,tryptase alpha/beta 1,TPS2,tryptase α...

Human HEK293 Cells
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s...
TMPJ-00375 HGF Protein, Human, Recombinant (His)

Scatter factor,Hepatocyte growth factor,HGF,SF,Hepatopoietin...

Human HEK293 Cells
HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelia...
TMPY-01589 Serpin B10 Protein, Mouse, Recombinant (His)

Serpinb10-ps,serpin peptidase inhibitor, clade B (o...

Mouse Baculovirus Insect Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhi...
TMPY-01900 Kallikrein 4/KLK4 Protein, Human, Recombinant (His)

PSTS,kallikrein,kallikrein-related peptidase 4,EMSP,EMSP...

Human HEK293 Cells
Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transi...
TMPY-01855 Serpin A10 Protein, Mouse, Recombinant (His)

serpin peptidase inhibitor, clade A (alpha-1 antipr...

Mouse HEK293 Cells
Protein Z-dependent protease inhibitor, also known as PZ-dependent protease inhibitor, SERPINA1 and ZPI, is a secreted protein that belongs to the serpin family. It is expressed by the liver and secreted in plasma. SERPINA1 / Serpin-A1 inhibits factor Xa activity in the presence of protein Z, calcium and phospholipid. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because ...
TMPJ-01032 SPINK7 Protein, Human, Recombinant (His)

ECG2,SPINK7,Serine protease inhibitor Kaza...

Human HEK293 Cells
Serine protease inhibitor Kazal-type 7(SPINK7) is a secreted protein, that in humans is encoded by the SPINK7 gene. SPINK7 contains 1 Kazal-like domain. SPINK7 is probably serine protease inhibitor. Recombinant human SPINK7 is a single, non-glycosylated polypeptide chain containing 74 amino acids and fused to His-tag at c-terminus.
TMPK-00923 FAP Protein, Mouse, Recombinant (His)

FAPα,FAPalpha,DPPIVA,APCE,SIMP,FAP,DPPIV,FAPA,Seprase

Mouse HEK293 Cells
Fibroblast activation protein (FAP) is a serine protease that has been reported in fibroblasts and some carcinoma cells, which correlates with poor patient outcomes. FAP can be induced under hypoxia which is also vital in the malignant behaviors of cancer cells. FAP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 86.4 kDa and the accession number is P97321-1.
TMPK-00373 FAP Protein, Human, Recombinant (hFc)

FAPA,SIMP,DPPIV,FAPα,FAP,Seprase,FAPalpha,DPPIVA,APCE

Human HEK293 Cells
Fibroblast activation protein (FAP) is a serine protease that has been reported in fibroblasts and some carcinoma cells, which correlates with poor patient outcomes. FAP can be induced under hypoxia which is also vital in the malignant behaviors of cancer cells. FAP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 112.3 kDa and the accession number is Q12884-1.
TMPK-00194 TFPI Protein, Human, Recombinant (His & Avi)

LACI,EPI,TFPI,convertin,TFI,TFPI1

Human HEK293 Cells
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1.
TMPK-00195 TFPI Protein, Human, Recombinant (His & Avi), Biotinylated

convertin,TFI,LACI,EPI,TFPI,TFPI1

Human HEK293 Cells
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1.
TMPY-01841 Serpin I2 Protein, Human, Recombinant (His)

PI14,TSA2004,PANCPIN,MEPI,Serpin I2,serpin peptidas...

Human HEK293 Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chy...
TMPK-01303 TPSAB1 protein, Cynomolgus, Recombinant (His)

Tryptase alpha/beta-1,TPSB1,Tryptase I,TPS...

Cynomolgus E. coli
TPSAB1, namely tryptase alpha/beta-1, is a serine protease with trypsin­like activity. TPSAB1 is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It may play a role in innate immunity. Diseases associated with TPSAB1 include mastocytosis and systemic mastocytosis.
TMPK-00274 PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated

QPD,Urokinase,BDPLT5,UPA,ATF,URK,u-PA,PLAU

Human HEK293 Cells
Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.3 kDa and the accession number is P0074...
TMPY-01363 Serpin A11 Protein, Mouse, Recombinant (His)

serpin peptidase inhibitor, clade A (α-1 antiprotei...

Mouse HEK293 Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhi...
TMPK-00755 Complement Factor D/CFD Protein, Human, Recombinant (hFc)

C3 convertase activator,DF,AMBP-1,EC 3.4.21

Human HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Human, Recom...
TMPJ-00625 Serpin E1 Protein, Mouse, Recombinant (His)

Pai1,Planh1,Plasminogen activator inhibito...

Mouse HEK293 Cells
Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
TMPK-00151 Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)

C3 convertase activator,AMBP-1,PFD,FACTOR D,CFD,ADN...

Mouse HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Mouse, Recom...
TMPY-01632 Serpin B4 Protein, Mouse, Recombinant (His)

Serpinb4,1110001H02Rik,<...

Mouse Baculovirus Insect Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhi...
TMPK-00671 Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)

Adipsin,CFD,ADN,Complement factor D,DF,AMBP-1,EC 3....

Rhesus HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Rhesus macaq...
TMPJ-00881 CTRB1 Protein, Human, Recombinant (His)

CTRB,CTRB1,Chymotrypsinogen B

Human HEK293 Cells
Chymotrypsinogen B (CTRB1) is a 263 amino acid protein with signal peptide (1-18) and Chymotrypsinogen B (19-263). Chymotrypsinogen B have three chains:Chymotrypsin B chain A(19-31), Chymotrypsin B chain B(34-164), Chymotrypsin B chain C (167-263). Chymotrypsinogen B is a Serine Protease Hydrolase secrets into gastrointestinal tract as the inactive precursor Chymotrypsinogen.
TMPY-01580 PRSS2 Protein, Mouse, Recombinant (His)

Tesp4,protease, serine 2,Try2,Ta,TRY8,TRYP...

Mouse HEK293 Cells
Trypsin-2, also known as Trypsin II, Anionic trypsinogen, Serine protease 2, PRSS2 and TRY2, is a secreted protein that belongs to the trypsin serine protease family including Trypsin, PRSS1, PRSS2 and PRSS3. It consists of a signal peptide (residues 1-15), a pro region (residues 16-23), and a proteolytically active mature chain (residues 24-247). PRSS2 contains one peptidase S1 domain. It is secreted into the duodenum, hydrolysing peptides into their smaller building blocks, which is necessary ...
TMPY-01854 DPP10 Protein, Human, Recombinant (His)

DPPY,DPRP3,DPRP-3,DPL2,dipeptidyl-peptidase 10 (non...

Human HEK293 Cells
Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally p...
TMPY-01814 GASP-1/WFIKKN2 Protein, Human, Recombinant (His)

WFIKKNRP,GASP-1,hGASP-1,WFDC20B,WAP, folli...

Human HEK293 Cells
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2, also known as Growth and differentiation factor-associated serum protein 1, WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing-related protein, WFIKKN-related protein, WFIKKN2 and GASP1, is a secreted protein that belongs to the WFIKKN family. WFIKKN2 contains two BPTI/Kunitz inhibitor domains, one Ig-like C2-type (immunoglobulin-like) domain, one Kazal-like domain, one NTR domain and one WAP domain. WFIKKN2 ...
TMPJ-00891 Kallikrein 2/KLK2 Protein, Human, Recombinant (His)

hGK-1,Kallikrein-2,Tissue Kallikrein-2,KLK2,Glandul...

Human HEK293 Cells
Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 ...
TMPY-01303 Serpin A3 Protein, Human, Recombinant (His)

ACT,GIG25,serpin peptidase inhibitor, clade A (alpha-1

Human HEK293 Cells
SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzy...
TMPY-00821 HGFA Protein (pro form), Human, Recombinant (His)

MGC138397,HGFA,RP11-529E1

Human HEK293 Cells
HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is clea...
TMPH-02237 TMPRSS2 Protein, Human, Recombinant (His & Myc)

Human HEK293 Cells
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....
TMPH-02236 TMPRSS2 Protein, Human, Recombinant (E. coli, His)

Human E. coli
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....
TMPY-02712 Serpin B3 Protein, Human, Recombinant (His)

T4-A,HsT1196,serpin peptidase inhibitor, c...

Human Baculovirus Insect Cells
SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be...
TMPY-01711 Serpin B2 Protein, Human, Recombinant (GST)

PAI,serpin peptidase inhibitor, clade B (ovalbumin), member ...

Human Baculovirus Insect Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein that belongs to the serpin fa...
TMPY-01027 Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)

carnitine palmitoyltransferase 1B (muscle),AV080368...

Mouse HEK293 Cells
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w...
TMPY-04451 AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)

AMPK, AMPK(α1, β1, γ1)

Human Baculovirus Insect Cells
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&Q13131-1.
TMPY-03878 Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)

Integrin alpha V β6,ITGAV & ITGB6,integrin, alpha 5 (fibrone...

Human HEK293 Cells
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-02501 CD3D & CD3E Heterodimer Protein, Human, Recombinant

CD3d molecule, δ (CD3-TCR complex),CD3-δ,CD3d molecule, delt...

Human HEK293 Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
TMPY-03745 CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)

CD3-DELTA,CD3d molecule, delta (CD3-TCR complex),CD3d molecu...

Human HEK293 Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPY-02245 SNAP-25 Protein, Human, Recombinant (His)

synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ

Human E. coli
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp...
TMPK-00383 ACE2/ACEH Protein, Human, Recombinant (His & Avi)

ACE2,ACE-2,ACEH

Human HEK293 Cells
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPY-01147 R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)

RSPO,CRISTIN3,R-spondin 1

Human HEK293 Cells
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is Q2MKA7-1.
TMPY-01850 CEACAM3 Protein, Human, Recombinant (His)

W282,W264,CEA,CD66D,CGM1,MGC11987...

Human HEK293 Cells
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexp...
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重组蛋白

Prostasin/PRSS8 Protein, Human, Recombinant (His)
Cat.No: TMPY-00905
Species: Human
Expression System: HEK293 Cells
Serpin A1a Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00452
Species: Mouse
Expression System: HEK293 Cells
Serpin A1e Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01069
Species: Mouse
Expression System: HEK293 Cells
Complement Factor MASP3 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00980
Species: Human
Expression System: HEK293 Cells
Prostasin/PRSS8 Protein, Mouse, Recombinant (aa 30-289, His)
Cat.No: TMPY-02783
Species: Mouse
Expression System: Baculovirus Insect Cells
Serpin E2 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01083
Species: Mouse
Expression System: HEK293 Cells
KLK10 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00468
Species: Human
Expression System: HEK293 Cells
SPINK1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00733
Species: Human
Expression System: HEK293 Cells
Anionic trypsin-1 Protein, Rat, Recombinant (E. coli, His)
Cat.No: TMPH-03242
Species: Rat
Expression System: E. coli
Anionic trypsin-1 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03243
Species: Rat
Expression System: P. pastoris (Yeast)
Cationic trypsin Protein, Canine, Recombinant (His & SUMO)
Cat.No: TMPH-00484
Species: Canine
Expression System: E. coli
TPSAB1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01204
Species: Human
Expression System: HEK293 Cells
HGF Protein, Human, Recombinant (His)
Cat.No: TMPJ-00375
Species: Human
Expression System: HEK293 Cells
Serpin B10 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01589
Species: Mouse
Expression System: Baculovirus Insect Cells
Kallikrein 4/KLK4 Protein, Human, Recombinant (His)
Cat.No: TMPY-01900
Species: Human
Expression System: HEK293 Cells
Serpin A10 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01855
Species: Mouse
Expression System: HEK293 Cells
SPINK7 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01032
Species: Human
Expression System: HEK293 Cells
FAP Protein, Mouse, Recombinant (His)
Cat.No: TMPK-00923
Species: Mouse
Expression System: HEK293 Cells
FAP Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00373
Species: Human
Expression System: HEK293 Cells
TFPI Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00194
Species: Human
Expression System: HEK293 Cells
TFPI Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00195
Species: Human
Expression System: HEK293 Cells
Serpin I2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01841
Species: Human
Expression System: HEK293 Cells
TPSAB1 protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01303
Species: Cynomolgus
Expression System: E. coli
PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00274
Species: Human
Expression System: HEK293 Cells
Serpin A11 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01363
Species: Mouse
Expression System: HEK293 Cells
Complement Factor D/CFD Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00755
Species: Human
Expression System: HEK293 Cells
Serpin E1 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00625
Species: Mouse
Expression System: HEK293 Cells
Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00151
Species: Mouse
Expression System: HEK293 Cells
Serpin B4 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01632
Species: Mouse
Expression System: Baculovirus Insect Cells
Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPK-00671
Species: Rhesus
Expression System: HEK293 Cells
CTRB1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00881
Species: Human
Expression System: HEK293 Cells
PRSS2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01580
Species: Mouse
Expression System: HEK293 Cells
DPP10 Protein, Human, Recombinant (His)
Cat.No: TMPY-01854
Species: Human
Expression System: HEK293 Cells
GASP-1/WFIKKN2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01814
Species: Human
Expression System: HEK293 Cells
Kallikrein 2/KLK2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00891
Species: Human
Expression System: HEK293 Cells
Serpin A3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01303
Species: Human
Expression System: HEK293 Cells
HGFA Protein (pro form), Human, Recombinant (His)
Cat.No: TMPY-00821
Species: Human
Expression System: HEK293 Cells
TMPRSS2 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-02237
Species: Human
Expression System: HEK293 Cells
TMPRSS2 Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-02236
Species: Human
Expression System: E. coli
Serpin B3 Protein, Human, Recombinant (His)
Cat.No: TMPY-02712
Species: Human
Expression System: Baculovirus Insect Cells
Serpin B2 Protein, Human, Recombinant (GST)
Cat.No: TMPY-01711
Species: Human
Expression System: Baculovirus Insect Cells
Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01027
Species: Mouse
Expression System: HEK293 Cells
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04451
Species: Human
Expression System: Baculovirus Insect Cells
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
Cat.No: TMPY-03878
Species: Human
Expression System: HEK293 Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant
Cat.No: TMPY-02501
Species: Human
Expression System: HEK293 Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)
Cat.No: TMPY-03745
Species: Human
Expression System: HEK293 Cells
SNAP-25 Protein, Human, Recombinant (His)
Cat.No: TMPY-02245
Species: Human
Expression System: E. coli
ACE2/ACEH Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00383
Species: Human
Expression System: HEK293 Cells
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01147
Species: Human
Expression System: HEK293 Cells
CEACAM3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01850
Species: Human
Expression System: HEK293 Cells
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